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KMID : 0351619700110020329
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Kyungpook Medical Journal
1970 Volume.11 No. 2 p.329 ~ p.334
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The Effect of Ethanol on the Liver Protein Synthesis of Normal and Ethionine Intoxicated Rats
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Abstract
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This paper presents results of experiments designed to evaluate the effects of acute ethanol administration on the protein synthesis of normal and ethionine intoxicated rat livers.
The incorporation of L-lysine-^(14)C into liver protein and serum protein, albumin and globulin, after subcutaneous administration of a single large dose of ethanol showed a significant increase after two hours to continue its increasing rate thereafter. The elevated protein syntheses began its decrease from the 16th hour. The increase of protein synthesis was more significant when the ethanol injection was repeated at interval of 4∼5 hours, and the synthesis nearly doubled 16 hours after the initial injection.
The effect of ethanol administration on protein synthesis of ethionine intoxicated rat livers was rather inhibitory.
In female rats, the ethionine induced depression of protein synthesis was more aggravated, especially in serum protein, by ethanol administration.
When cirrhotic rats, after being fed 0.25% DL-ethionine diet for 6 months, were administered ethanol in fast, the synthesis of albumin in liver, which was most depressed in the cirrhotic liver, was strikingly increased where the increase of globulin synthesis was less significant.
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